RAPID COMMUNICATION ENL, the Gene Fused With HRX in t ( l1; 19) Leukemias, Encodes a Nuclear Protein With Transcriptional Activation Potential in Lymphoid and Myeloid Cells
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چکیده
Chromosome band 1 lq23 is the site of recurring translocations with a variety of partner chromosomes in myeloid and lymphoid acute leukemias, infant leukemias, and treatmentinduced secondary acute myelogenous leukemia. The translocation breakpoints cluster in a restricted region of the HRX gene resulting in fusion genes that encode an N-terminal portion of Hrx fused to various partner proteins. We have characterized the transcriptional transactivation properties of Enl, a protein that is fused to Hrx in t(l1; 19) leukemias. En1 is a nuclear protein that is capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid
منابع مشابه
The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.
The HRX gene (also called MLL, ALL-1, and Htrx) at chromosome band 11q23 is associated with specific subsets of acute leukemias through translocations that result in its fusion with a variety of heterologous partners. Two of these partners, ENL and AF9, code for proteins that are highly similar to each other and as fusions with HRX induce myeloid leukemias in mice as demonstrated by retroviral ...
متن کاملThe HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures.
Chromosomal rearrangement of the HRX (MLL, ALL-1, Htrx) gene situated at chromosome band 11q23 is one of the most frequent genetic changes in infant leukemias of myeloid and lymphoid lineage and in treatment-induced secondary leukemias. The HRX gene codes for a predicted 431-kD protein that shows significant homology to the Drosophila trithorax protein, an Hox epigenetic regulator. Typically, t...
متن کاملH R X Involvement in De Novo and Secondary Leukemias With Diverse Chromosome l l q 2 3 Abnormalities
Chromosome band 1 1 q23 is a site of recurrent translocations and interstitial deletions in human leukemias. Recent studies have shown that the 1 1 q23 gene HRX is fused to heterologous genes from chromosomes 4 or 19 after t(4;l l)(q21 ;q23) and t(ll;19)(q23; p l3 ) translocations to create fusion genes encoding proteins with structural features of chimeric transcription factors. In this report...
متن کاملA serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.
Translocations involving chromosome band 11q23 in acute leukemias have recently been shown to involve the HRX gene that codes for a protein with significant similarity to Drosophila trithorax. HRX gene alterations are consistently observed in t(4;11) (q21;q23)-carrying leukemias and cell lines by Southern blot analyses and are accompanied by HRX transcripts of anomalous size on Northern blots. ...
متن کاملMolecular Analysis of t ( l 1 ; 19 ) Breakpoints in Childhood Acute Leukemias
MLL is fused to ENL or ELL in acute leukemias that contain t(l1; 191(q23;p131. Although ENL and ELL localize to chromosome 19, bands p13.3 and p13.1, respectively, these breakpoints are not always readily distinguished by standard cytogenetics. We therefore used reversa transcriptasepolymerase chain reaction (RT-PCR) assays to analyze 26 cases of childhood acute leukemia containing t(l1; 19) to...
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تاریخ انتشار 2000